Nah it's entirely dependant upon marksmanship. I'll hunt white tail with a 22-250 on occasion, but I'm not exactly a run-of-the-mill marksman, and I prefer my 7mm Magnum (roughly .275 calibre) because of round stabillity and range. Though I agree with you; .22 calibre weapons should generally be used for smaller game.
Oh I love people who grew up always having food on the table.
opcorn: