Short lifespans

Catsi

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#1
Why is it that some breeds have short life spans? I'm thinking Berners, Saints, Danes, IWs etc.

I know size has something to do with it. But why? What can be done to improve life expectancy?
 

GoingNowhere

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#4
Something interesting from this link that I searched after reading something similar in a new book:

http://www.insidescience.org/content/large-dogs-age-faster-die-younger/953

"One intriguing clue, gleaned from previous studies, is that small dogs have lower concentrations of the growth hormone IGF-1, or insulin-like growth factor 1, in their blood than large dogs.

High levels of IGF-1 has been shown in a wide variety of organisms, including humans, to be associated with increased risk of death from age-related diseases such as cancer and heart disease. Conversely, manipulations that lower IGF-1 levels in many animal species slow their rates of aging, reduce the risks of age-related disease and extend their lifespans."
 

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