Proin--Killer of Dogs!! (Incontinence Drug)
- Thread starter Corky/Max
- Start date
What i was getting at (wich most people caught on) is how many dogs are on the medication in the US? How many died from alleged complications due to this drug? If it is only 1/1000 dogs dieing, then I would take the chance if there was no other option.
Emma was on Pred. Its not a nice drug. Some dogs dont do well on it. However it was try it or die. So I tried it, and she was lucky she did OK on it.
Emma was on Pred. Its not a nice drug. Some dogs dont do well on it. However it was try it or die. So I tried it, and she was lucky she did OK on it.
Almost any medication has a "severe" side effect with the potential for death/coma. Example, my medication for Rheumatoid arthritis. Side effects or potential ones:
I took this stuff EVERY day for a year until I found out I was pregnant, then stopped because it can cause birth defects. Is it likely I"m going to keel over from it? No it's not, but it's a potential. You have to weigh the risks versus the benefits. Risk: dying or liver failure...benefit: I don't suffer with extreme pain daily.
If I happen to pass this along to my children I would rather they took something that saves them from the severe daily pain of having RA with a tiny risk of complications. There's that 1/1000 risk, but living with a s evere medical problem is no way to live.
I took this stuff EVERY day for a year until I found out I was pregnant, then stopped because it can cause birth defects. Is it likely I"m going to keel over from it? No it's not, but it's a potential. You have to weigh the risks versus the benefits. Risk: dying or liver failure...benefit: I don't suffer with extreme pain daily.
If I happen to pass this along to my children I would rather they took something that saves them from the severe daily pain of having RA with a tiny risk of complications. There's that 1/1000 risk, but living with a s evere medical problem is no way to live.
The whole point is to make an EDUCATED decision. Your decision. There should be full disclosure as to ALL the hazards a drug poses.
Right now the pharmaceutical industry has found a mother lode. Pet meds. Crank 'em out, get the next *miracle* out there to the populace that is dedicated to their pets; nevermind that some of them are barely past the level of assurance of Dr. Jekyll's experiment, there very limited liability for killing pets, so what have they got to lose? Especially since we're willing to pay charges for these drugs that are as high as if they WERE thoroughly tested.
Right now the pharmaceutical industry has found a mother lode. Pet meds. Crank 'em out, get the next *miracle* out there to the populace that is dedicated to their pets; nevermind that some of them are barely past the level of assurance of Dr. Jekyll's experiment, there very limited liability for killing pets, so what have they got to lose? Especially since we're willing to pay charges for these drugs that are as high as if they WERE thoroughly tested.
what alternatives? the only one i know of is DES, which also has potential serious side-effects (bone marrow suppression leading to anemia- not at all common at the dose used for treating incontinence, but possible). not treating it also has potential side-effects, including urinary tract infections, which then must be treated with antibiotics, which carry the potential for side-effects.
There are herbal and homeopathic alternatives, sometimes chiropractic can help, diapers and pads to minimize the clean up.
Ares has incontinence. I've looked into PPA and some of the herbal stuff and have been able for now to manage with some adjustments to his potty/feed/water schedule. If it worsens as he ages, my next choice will probably to try chiro and/or diapers. I just don't like giving him much of anything as far as meds go, so unless the incontinence starts to cause problems beyond extra cleaning I won't.
Ares has incontinence. I've looked into PPA and some of the herbal stuff and have been able for now to manage with some adjustments to his potty/feed/water schedule. If it worsens as he ages, my next choice will probably to try chiro and/or diapers. I just don't like giving him much of anything as far as meds go, so unless the incontinence starts to cause problems beyond extra cleaning I won't.
This is a copy of something I posted on the other forum I am in: Corky/Max
Senior Member
Best In Show
Incontinence--Alternative Meds to 'KILLER' Proin
Off the net:
Treating incontinence in dogs
Question: Dear Dr; I have a dog with spayed female incontinence. For over a year I have treated her with ppa (acutrim) with total success. Unfortunately, this drug is now unavailable. Hormonal tx is out of the question since she has liver disease. My vet has no answer for me, and I am at my wit's end. Any suggestions? Thanks in advance Annette
Answer: Annette-
I am sorry for the delay in replying to your question. There are several medications that are currently being used to treat incontinence in dogs in an effort to find one that replaces phenylpropanolamine (PPA). They are:
1) Diethylstilbestrol (DES), which is a synthetic form of estrogen. There is some fear of bone marrow suppression when using DES but I do no recall ever experiencing this problem in practice, so I presume it is rare. I know of no reason that DES can not be used when there are changes in liver function, but your vet may know something that I do not. DES is currently only available from compounding pharmacies but all the ones that we deal with have it, so it is readily available.
2) Imipramine (Tofranil Rx), a tricyclic antidepressant, causes urine retention in some patients treated with it, so it is being used in the hopes this effect will occur in patients with incontinence. Initial reports are encouraging, but that is often the case when people are looking for a substitute for a medication and want to have good results.
3) Pseudoephedrine (Sudafed tm) causes similar effects to phenylpropanolamine but has not been used extensively. The dosage is 30mg for small dogs and 60mg for big dogs. I have been using 30 lbs. of bodyweight as the dividing line between large and small. I have not had enough reports back from owners yet to know if this is working at all.
4) Some compounding pharmacies still have phenylpropanolamine powder and can custom make capsules with the appropriate dose for a patient who needs this medication. It is worth calling around to the various compounding pharmacies (or checking online for veterinary compounding pharmacies) to see if one of them has this medication. Your vet should know of some of these, as well. There are several that advertise nationally.
Good luck with this. I hope that one of these suggestions is helpful if you have not already found a solution to the problem.
Mike Richards, DVM 1/8/2001
Phenylpropanolamine's alternatives
Question: Hi, Dr. Mike -
I'm sure I won't be the first, nor the last, of your clients/correspondees to ask just what you will recommend to take the place of the now-defunct phenylpropanolamine. I am just sick that I can no longer obtain Dexatrim, or other OTC meds, to control BOTH Trudi's and her Boxer-sister-Fanci's (Fanci's is the typical spayed-female-leakage, brought on by advancing years) incontinence.
A brief note on our CRF gal, Trudi. Twenty-two months after the original diagnosis of chronic CRF was handed down, she is still doing remarkably well. The herbal iron tonic I discovered about 4 mos. ago has really created a huge improvement in her looks, stamina, eating patterns, demeanor. We continue to have small episodes of pancreatitis, which (so far) can be controlled by removing all food for 24 hrs. Strangely, although she LOOKS so great, her blood chem values have changed little; outwardly, the only sign that she's a CRF gal is her constant-and-profuse shedding.
Dr. Mike, I sure hope you'll be able to give us a tip as to what (either OTC or Rx) we can use to control the incontinence from now on. Thanks in advance.........your advice has always been valuable to us!
Regards, Rozanne
Answer: Rozanne-
Phenylpropanolamine is still available from some compounding pharmacies. I know of at least two in our area that still have the powder to make this medication and I believe that it may remain available through compounding pharmacies.
There are alternatives to phenylpropanolamine. The one currently being talked about the most on the Veterinary Information Network (Veterinary Information Network (VIN) - For Veterinarians, By Veterinarians, a service for veterinarians only) bulletin boards is impramine (Tofranil Rx), 1 to 2mg/kg of body weight every 12 hours, up to 15mg twice a day. I have not used this medication because we have had good success using diethylstilbestrol (DES) and have been able to obtain this medication from our local compounding pharmacy. We usually use 0.5mg per day for 5 days for small dogs, or 1mg per day for large dogs. We then try to lengthen the interval, usually reaching a once weekly or twice weekly dosage in most female patients. We usually try testosterone in male dogs but generally have to combine this with something else, such as phenylpropanolamine, so when our supply of this runs out, we will have to consider other options for our male patients, probably. I am hoping that when we run out of phenylpropanolamine the compounding pharmacies will still be able to get the medication.
Mike Richards, DVM 12/4/2000
Leaking urine and accidents - medication related in Samoyed
Question: Help! My samoyed has suddenly forgotten what it means to be house trained. She is currently on medication for myositis, predinose 30mg every other day, and when she started to leak urine, she was put on phenylpropanolamine (now down to 25mg on the days she gets her prednisone). In the last week, she has started to have accidents in the house, even after she is brought in after being out for a while. I let her out several times during the night and still she slips. Is this related to the medication? Thanks. P.A.
Answer: P.A.-
It is very likely that there is a relationship to the medication with the sudden change in urinary habits. Sometimes prednisone can make it easy for bladder infections to occur, so it would be worth having her checked by your vet for this. Bringing a urine sample that is less than 4 hours old can be helpful, just in case it isn't possible to get a urine sample at the vet's office. Prednisone can also sometimes push a dog with a tendency towards diabetes into exhibiting signs of that disease and the urine will help to rule that out.
If the urination problems are not related to cystitis there is still a chance that the prednisone is contributing, since it does make dogs drink more and urinate more. In that case, it may be necessary to try to find a lower dose that will control the myositis but not induce excessive urination. Sometimes it isn't possible to do that but it is worth trying.
Sometimes when dogs start to have accidents in the house for medical reasons the behavior becomes self supporting since dogs like to urinate where they have urinated before. Cleaning the area carefully with an enzymatic cleaner and working hard to catch her urinating so that you can reinforce that it is not acceptable behavior with a loud "NO" can help to restore her old and better habits.
I think I also may find more on natural methods in that same forum--I will go see but have to quit here for awhile! :lol-sign: My dog needs his supper! Be back --hopefully with more a little later!
Senior Member
Best In Show
Incontinence--Alternative Meds to 'KILLER' Proin
Off the net:
Treating incontinence in dogs
Question: Dear Dr; I have a dog with spayed female incontinence. For over a year I have treated her with ppa (acutrim) with total success. Unfortunately, this drug is now unavailable. Hormonal tx is out of the question since she has liver disease. My vet has no answer for me, and I am at my wit's end. Any suggestions? Thanks in advance Annette
Answer: Annette-
I am sorry for the delay in replying to your question. There are several medications that are currently being used to treat incontinence in dogs in an effort to find one that replaces phenylpropanolamine (PPA). They are:
1) Diethylstilbestrol (DES), which is a synthetic form of estrogen. There is some fear of bone marrow suppression when using DES but I do no recall ever experiencing this problem in practice, so I presume it is rare. I know of no reason that DES can not be used when there are changes in liver function, but your vet may know something that I do not. DES is currently only available from compounding pharmacies but all the ones that we deal with have it, so it is readily available.
2) Imipramine (Tofranil Rx), a tricyclic antidepressant, causes urine retention in some patients treated with it, so it is being used in the hopes this effect will occur in patients with incontinence. Initial reports are encouraging, but that is often the case when people are looking for a substitute for a medication and want to have good results.
3) Pseudoephedrine (Sudafed tm) causes similar effects to phenylpropanolamine but has not been used extensively. The dosage is 30mg for small dogs and 60mg for big dogs. I have been using 30 lbs. of bodyweight as the dividing line between large and small. I have not had enough reports back from owners yet to know if this is working at all.
4) Some compounding pharmacies still have phenylpropanolamine powder and can custom make capsules with the appropriate dose for a patient who needs this medication. It is worth calling around to the various compounding pharmacies (or checking online for veterinary compounding pharmacies) to see if one of them has this medication. Your vet should know of some of these, as well. There are several that advertise nationally.
Good luck with this. I hope that one of these suggestions is helpful if you have not already found a solution to the problem.
Mike Richards, DVM 1/8/2001
Phenylpropanolamine's alternatives
Question: Hi, Dr. Mike -
I'm sure I won't be the first, nor the last, of your clients/correspondees to ask just what you will recommend to take the place of the now-defunct phenylpropanolamine. I am just sick that I can no longer obtain Dexatrim, or other OTC meds, to control BOTH Trudi's and her Boxer-sister-Fanci's (Fanci's is the typical spayed-female-leakage, brought on by advancing years) incontinence.
A brief note on our CRF gal, Trudi. Twenty-two months after the original diagnosis of chronic CRF was handed down, she is still doing remarkably well. The herbal iron tonic I discovered about 4 mos. ago has really created a huge improvement in her looks, stamina, eating patterns, demeanor. We continue to have small episodes of pancreatitis, which (so far) can be controlled by removing all food for 24 hrs. Strangely, although she LOOKS so great, her blood chem values have changed little; outwardly, the only sign that she's a CRF gal is her constant-and-profuse shedding.
Dr. Mike, I sure hope you'll be able to give us a tip as to what (either OTC or Rx) we can use to control the incontinence from now on. Thanks in advance.........your advice has always been valuable to us!
Regards, Rozanne
Answer: Rozanne-
Phenylpropanolamine is still available from some compounding pharmacies. I know of at least two in our area that still have the powder to make this medication and I believe that it may remain available through compounding pharmacies.
There are alternatives to phenylpropanolamine. The one currently being talked about the most on the Veterinary Information Network (Veterinary Information Network (VIN) - For Veterinarians, By Veterinarians, a service for veterinarians only) bulletin boards is impramine (Tofranil Rx), 1 to 2mg/kg of body weight every 12 hours, up to 15mg twice a day. I have not used this medication because we have had good success using diethylstilbestrol (DES) and have been able to obtain this medication from our local compounding pharmacy. We usually use 0.5mg per day for 5 days for small dogs, or 1mg per day for large dogs. We then try to lengthen the interval, usually reaching a once weekly or twice weekly dosage in most female patients. We usually try testosterone in male dogs but generally have to combine this with something else, such as phenylpropanolamine, so when our supply of this runs out, we will have to consider other options for our male patients, probably. I am hoping that when we run out of phenylpropanolamine the compounding pharmacies will still be able to get the medication.
Mike Richards, DVM 12/4/2000
Leaking urine and accidents - medication related in Samoyed
Question: Help! My samoyed has suddenly forgotten what it means to be house trained. She is currently on medication for myositis, predinose 30mg every other day, and when she started to leak urine, she was put on phenylpropanolamine (now down to 25mg on the days she gets her prednisone). In the last week, she has started to have accidents in the house, even after she is brought in after being out for a while. I let her out several times during the night and still she slips. Is this related to the medication? Thanks. P.A.
Answer: P.A.-
It is very likely that there is a relationship to the medication with the sudden change in urinary habits. Sometimes prednisone can make it easy for bladder infections to occur, so it would be worth having her checked by your vet for this. Bringing a urine sample that is less than 4 hours old can be helpful, just in case it isn't possible to get a urine sample at the vet's office. Prednisone can also sometimes push a dog with a tendency towards diabetes into exhibiting signs of that disease and the urine will help to rule that out.
If the urination problems are not related to cystitis there is still a chance that the prednisone is contributing, since it does make dogs drink more and urinate more. In that case, it may be necessary to try to find a lower dose that will control the myositis but not induce excessive urination. Sometimes it isn't possible to do that but it is worth trying.
Sometimes when dogs start to have accidents in the house for medical reasons the behavior becomes self supporting since dogs like to urinate where they have urinated before. Cleaning the area carefully with an enzymatic cleaner and working hard to catch her urinating so that you can reinforce that it is not acceptable behavior with a loud "NO" can help to restore her old and better habits.
I think I also may find more on natural methods in that same forum--I will go see but have to quit here for awhile! :lol-sign: My dog needs his supper! Be back --hopefully with more a little later!
Some More Alternatives--
kaandu Proin 50
I wish I would have known about this forum yesterday. Our 13 year old dog was having an incontinence problem and the vet put her on Proin 50. Within 1 hour after taking her first (and only) pill she collapsed and started having a seizure. Within another hour she was dead. I was given no warning about the dangers of this drug and would much rather have put up with the urine as you said than to not have my beloved dog any longer. I should have searched online about this medication before giving it to her rather than after losing her.
kaandu
06-17-2008 #3
mylittlebecky
Oh my gosh, I'm so sorry! That's awful!
I wanted to also let you know, in the future if you have other female dogs who are incontinent, I've found the natural bladder support products I've found online can be very helpful. There are several different brands, etc but I've found this one to be great!This is the link she gave about it--Would not show on this pasted copy--why I don't understand so I am now attempting to add it myself (Corky/Max):---see link at end of this paragraph---> Of course, you should always consult with a veterinarian when first trying these things to rule out UTI and possible interactions with any other medication your dog might be taking.LINK: Botanical Dog - Botanical Cat: PET NATURALS Bladder Support for Dogs-45 or 90 Tablets, Vitamins and Supplements
Again, I am so sorry for your loss. This is so hard and I hope you'll be able to find peace that you were only trying to help your dog get better with the advice of a veterinarian that you trusted.
mylittlebecky
12-15-2008 #6
trialsrider
I had to register to say that we did stop giving our dog Proin and replaced them with the natural bladder control pills which is more cheaper & she seems to love them! And yes it's been about a week and seems to be doing its job.
I'm very sorry for those that lost their beloved pet due to this medication
Kate52 Alternative to Proin
My vet suggested Proin for my GS. Having recently had a bad experience with another suggested prescription I decided to do a little research first.
I found a homeopathic alternative that seems to be working for my Lily without all of the potential problems mentioned in the forum. Please note that we have been using this for less than a week, but so far - so good.
The product is Homeopet "Leak No More". It is a liquid that you put on their food and the dosing is based on weight. Maybe it will work for others.
------------------------------------------------------------------
ntrep
Join Date: Feb 2009
Location: Chicago
hi all. I wish that I had read these sooner. I didn't realize that Proin was such a problem. I have a 15 year old English Setter who has an incontinence problem. He also has the onset of renal failure. The vet put him on the proin (25mg 2x/day). It didn't do much good so he upped it to 3x/day. that helped with the incontinence, but less than 3-4 days on the increased dose, my dog had a stroke and seizure. This was the most terrifying thing that I have ever seen. Fortunately, he survived and is learning to walk and get around the house again. You can be sure that he will never take the proin again. I take him out constantly and we keep puppy training pads everywhere. This has been a grueling experience for our entire family.
THis could be a helpful link:Incontinence - Dog Health & Nutrition - Dog Forums - I-Love-Dogs.com
There is more to follow this--stay tuned!
kaandu Proin 50
I wish I would have known about this forum yesterday. Our 13 year old dog was having an incontinence problem and the vet put her on Proin 50. Within 1 hour after taking her first (and only) pill she collapsed and started having a seizure. Within another hour she was dead. I was given no warning about the dangers of this drug and would much rather have put up with the urine as you said than to not have my beloved dog any longer. I should have searched online about this medication before giving it to her rather than after losing her.
kaandu
06-17-2008 #3
mylittlebecky
Oh my gosh, I'm so sorry! That's awful!
I wanted to also let you know, in the future if you have other female dogs who are incontinent, I've found the natural bladder support products I've found online can be very helpful. There are several different brands, etc but I've found this one to be great!This is the link she gave about it--Would not show on this pasted copy--why I don't understand so I am now attempting to add it myself (Corky/Max):---see link at end of this paragraph---> Of course, you should always consult with a veterinarian when first trying these things to rule out UTI and possible interactions with any other medication your dog might be taking.LINK: Botanical Dog - Botanical Cat: PET NATURALS Bladder Support for Dogs-45 or 90 Tablets, Vitamins and Supplements
Again, I am so sorry for your loss. This is so hard and I hope you'll be able to find peace that you were only trying to help your dog get better with the advice of a veterinarian that you trusted.
mylittlebecky
12-15-2008 #6
trialsrider
I had to register to say that we did stop giving our dog Proin and replaced them with the natural bladder control pills which is more cheaper & she seems to love them! And yes it's been about a week and seems to be doing its job.
I'm very sorry for those that lost their beloved pet due to this medication
Kate52 Alternative to Proin
My vet suggested Proin for my GS. Having recently had a bad experience with another suggested prescription I decided to do a little research first.
I found a homeopathic alternative that seems to be working for my Lily without all of the potential problems mentioned in the forum. Please note that we have been using this for less than a week, but so far - so good.
The product is Homeopet "Leak No More". It is a liquid that you put on their food and the dosing is based on weight. Maybe it will work for others.
------------------------------------------------------------------
ntrep
Join Date: Feb 2009
Location: Chicago
hi all. I wish that I had read these sooner. I didn't realize that Proin was such a problem. I have a 15 year old English Setter who has an incontinence problem. He also has the onset of renal failure. The vet put him on the proin (25mg 2x/day). It didn't do much good so he upped it to 3x/day. that helped with the incontinence, but less than 3-4 days on the increased dose, my dog had a stroke and seizure. This was the most terrifying thing that I have ever seen. Fortunately, he survived and is learning to walk and get around the house again. You can be sure that he will never take the proin again. I take him out constantly and we keep puppy training pads everywhere. This has been a grueling experience for our entire family.
THis could be a helpful link:Incontinence - Dog Health & Nutrition - Dog Forums - I-Love-Dogs.com
There is more to follow this--stay tuned!
Last edited:
You may find this interesting---------
From another forum (I pasted this in the I Love Dogs forum from another dog forum)
Does anyone know if it is safe to give Proin, phenylpropanolamine HCl,
to a dog that has fairly severe pulmonary hypertension? My dog's vet prescribed some today but just wanted to get second opinion. She is on lasix but nothing else for the pulmonary hypertension.
cgg Posted: Tue Aug 04, 2009 5:51 am
Post subject:
I'd certainly ask the vet to look into it.
Quote:
Side Effects
The most common side effects are pale gums, and difficulty urinating. More rarely, Proin causes restlessness, excitability, irritability, hypertension, anorexia or decreased appetite. The chance of hypertension occurring is greater if Proin is given together with non-steroidal anti-inflammatoriy drugs (NSAIDs), or with reserpine, tricyclic antidepressants, amitraz (the active ingredient of the Preventic tick control collar and canine Promeris, a flea control product), or ganglionic blocking agents. Proin can also cause ill effects in animals with preexisting conditions such as glaucoma, prostatic hypertrophy, hypertension, hyperthyroidism, diabetes mellitus, and cardiovascular disorders, or if administered in conjunction with other sympathomimetic drugs such as ephedrine or epinephrine.
jasminesmom
Post subject: Re: Proin
I hope you did not give ProIn. My Jasmine took it for 3 days, stopped eating, developed kidney failure and passed 9-04-09. It is really terrible stuff-it used to be known as Dexatrim and they took that off the market for humans. Let me know how shes doing please
If your dog has ANY underlying health issue they will suffer deadly side effects. Dexatrim was causing stokes in young women, so they took if off the market. ProIn, caused my Jasmine to stop eating and it caused kidney failure and she suffered from July 23, 2009 (her first does) until she passed 9-04-09. Please find another way to stop incontinenece
Corky/Max: I came across this forum after putting--Proin/adverse reactions in my browser. I hope Jasminesmom doesn't mind me
adding this 'conversation' to this forum! I wanted everyone to see the 1st post with the question and your answer here because of the sentences especially--to be aware of the 'alias' name for Proin and that it caused
strokes in young women!
Corky/Max: Does this not show you that because the pharmaceutical companies can no longer make money off of humans--It gets passed to our poor innocent dogs so the money keeps coming in!!
Corky/Max
09-25-2009 #68
cherylmartin
Senior Member
You may use anything I have to say about ProIn for I am only speaking from my experience. I heard from Pegasus Lab today and after talking with my vet concluded that ProIn did not cause her death. Well I tend to disagree. Jasmine was healthy since pancreatits in 2006! Took ProIn developed kidney failure then she was gone. The only way we can stop this is for all effected by ProIn to contact Pegasus Las via their web site and let FDA know of side effects-I'm doing that next.
cherylmartin
09-25-2009 #69
Corky/Max
Senior Member
-Quote/Cheryl:
went and told the vet of the side effects Jasmine was having, loss of appetite after the first dose-her remark to me was that she knew of no side effects. Well after some other things that transpired, I changed vets. The week after Jasmine passed I was able to sit down and write the vet and showed her what I saw at Pet Meds and other sites, indicating the side effects and most importantly it was not to be given if heart conditions present. Jasmine's heart murmur was a 4 out of 10 the day I went in to get something for incontinence ProIn so to me that's a heart condition. Ya know even a phone call saying I'm sorry would be nice.
Corky/Max:
Copied and pasted this here because--A lot of dogs have heart mur-murs--Both of mine do. And if your vet doesn't check for this there are prob. a lot of dogs that have it and you wouldn't even know about it unless your dog had it well advanced as eairlier stages/grades are not that noticeable! And I also wonder why so many dogs have mur-murs!! Even wondering if it has to do with too much stress on their immune systems from too many vaccinations and the bad, deadly prescriptions and the crappy commercial dog food they are fed that is slowly starving them from proper nutrition. The vet actually told me that it isn't uncommon for dogs to develop mur-murs almost as if it is expected!!! But why!!?? At least I know my 2 don't get commercial dog food--They are raw-fed and some home-cooking! I have said this many times--I feel so sorry for poor innocent dogs who depend on us to take good care of them! They are bombarded from every direction by greedy pharmeceutical co; unfit dog food; greedy or ignorant vets (kept in the dark--schooled by the 2 above mentioned. And then there are some good vets that have lost their license because they dared to disagree with the 2 above mentioned companies. This world is definitely run by greed!!!
Corky/Max
09-25-2009 #70
cherylmartin
Senior Member
Well when my vet: 1) knowlingly gave ProIn to Jasmine, with a heart murmur and it clearly stated do not give if heart condition and when she 2) gave her diatro (Lomotil not approved by FDA for use in animals but vets CAN still write prescriptions) for diarehha and my new vet saw where it is not to be given to dogs with kidney failure. I believe vets need to be made accountable just like human doctors. I intend to file a complaint with the DVM in Georgia.
From another forum (I pasted this in the I Love Dogs forum from another dog forum)
Does anyone know if it is safe to give Proin, phenylpropanolamine HCl,
to a dog that has fairly severe pulmonary hypertension? My dog's vet prescribed some today but just wanted to get second opinion. She is on lasix but nothing else for the pulmonary hypertension.
cgg Posted: Tue Aug 04, 2009 5:51 am
Post subject:
I'd certainly ask the vet to look into it.
Quote:
Side Effects
The most common side effects are pale gums, and difficulty urinating. More rarely, Proin causes restlessness, excitability, irritability, hypertension, anorexia or decreased appetite. The chance of hypertension occurring is greater if Proin is given together with non-steroidal anti-inflammatoriy drugs (NSAIDs), or with reserpine, tricyclic antidepressants, amitraz (the active ingredient of the Preventic tick control collar and canine Promeris, a flea control product), or ganglionic blocking agents. Proin can also cause ill effects in animals with preexisting conditions such as glaucoma, prostatic hypertrophy, hypertension, hyperthyroidism, diabetes mellitus, and cardiovascular disorders, or if administered in conjunction with other sympathomimetic drugs such as ephedrine or epinephrine.
jasminesmom
Post subject: Re: Proin
I hope you did not give ProIn. My Jasmine took it for 3 days, stopped eating, developed kidney failure and passed 9-04-09. It is really terrible stuff-it used to be known as Dexatrim and they took that off the market for humans. Let me know how shes doing please
If your dog has ANY underlying health issue they will suffer deadly side effects. Dexatrim was causing stokes in young women, so they took if off the market. ProIn, caused my Jasmine to stop eating and it caused kidney failure and she suffered from July 23, 2009 (her first does) until she passed 9-04-09. Please find another way to stop incontinenece
Corky/Max: I came across this forum after putting--Proin/adverse reactions in my browser. I hope Jasminesmom doesn't mind me
adding this 'conversation' to this forum! I wanted everyone to see the 1st post with the question and your answer here because of the sentences especially--to be aware of the 'alias' name for Proin and that it caused
strokes in young women!
Corky/Max: Does this not show you that because the pharmaceutical companies can no longer make money off of humans--It gets passed to our poor innocent dogs so the money keeps coming in!!
Corky/Max
09-25-2009 #68
cherylmartin
Senior Member
You may use anything I have to say about ProIn for I am only speaking from my experience. I heard from Pegasus Lab today and after talking with my vet concluded that ProIn did not cause her death. Well I tend to disagree. Jasmine was healthy since pancreatits in 2006! Took ProIn developed kidney failure then she was gone. The only way we can stop this is for all effected by ProIn to contact Pegasus Las via their web site and let FDA know of side effects-I'm doing that next.
cherylmartin
09-25-2009 #69
Corky/Max
Senior Member
-Quote/Cheryl:
went and told the vet of the side effects Jasmine was having, loss of appetite after the first dose-her remark to me was that she knew of no side effects. Well after some other things that transpired, I changed vets. The week after Jasmine passed I was able to sit down and write the vet and showed her what I saw at Pet Meds and other sites, indicating the side effects and most importantly it was not to be given if heart conditions present. Jasmine's heart murmur was a 4 out of 10 the day I went in to get something for incontinence ProIn so to me that's a heart condition. Ya know even a phone call saying I'm sorry would be nice.
Corky/Max:
Copied and pasted this here because--A lot of dogs have heart mur-murs--Both of mine do. And if your vet doesn't check for this there are prob. a lot of dogs that have it and you wouldn't even know about it unless your dog had it well advanced as eairlier stages/grades are not that noticeable! And I also wonder why so many dogs have mur-murs!! Even wondering if it has to do with too much stress on their immune systems from too many vaccinations and the bad, deadly prescriptions and the crappy commercial dog food they are fed that is slowly starving them from proper nutrition. The vet actually told me that it isn't uncommon for dogs to develop mur-murs almost as if it is expected!!! But why!!?? At least I know my 2 don't get commercial dog food--They are raw-fed and some home-cooking! I have said this many times--I feel so sorry for poor innocent dogs who depend on us to take good care of them! They are bombarded from every direction by greedy pharmeceutical co; unfit dog food; greedy or ignorant vets (kept in the dark--schooled by the 2 above mentioned. And then there are some good vets that have lost their license because they dared to disagree with the 2 above mentioned companies. This world is definitely run by greed!!!
Corky/Max
09-25-2009 #70
cherylmartin
Senior Member
Well when my vet: 1) knowlingly gave ProIn to Jasmine, with a heart murmur and it clearly stated do not give if heart condition and when she 2) gave her diatro (Lomotil not approved by FDA for use in animals but vets CAN still write prescriptions) for diarehha and my new vet saw where it is not to be given to dogs with kidney failure. I believe vets need to be made accountable just like human doctors. I intend to file a complaint with the DVM in Georgia.