I actually love that one of your grandpa's hand. It speaks to me too, even before you said who it was of. I don't have to know whose hand it is or have the backstory... the photo tells me. The person it tells ME it is may not be the same person it tells YOU it is, but that's not the point IMHO. We don't have to be thinking of the same person or the same individual, or even the same KIND of individual. It does work for me. Art won't speak to everybody and it also won't speak to everybody the same, but that doesn't make it no good or that it doesn't work. =>
It may be more appealing in black & white, but the colours in his skintone really struck me. I think you'd probably lose the white knuckled intensity in B&W... it's sort of a tough one. But personally, I really do like it.
The contrast in the first one seems a teensy bit off to me, but I like the shot a lot. The composition is very nice.
The second through fifth ones might be more interesting from a different angle, but as it is I'm not really finding anything spectacular in them. I like the balance of the second one - how his shirt in the top right corner is blue and her sleeve in the bottom left is blue - but I really wish you had been shooting from a lower position for that one!
I agree with Zoom about the seventh photo. The first puzzle photo is interesting, but the second puzzle photo strikes me more, perhaps because the shot is tighter. I love it. I'm guessing the first one is three generations? I really like that idea but the second shot is just more visually interesting to me.
The last one is very cute and a lovely shot, but the focus is her shoe rather than the hands or the action of the hands putting on a shoe. I'm not sure if you took the colour out of the shoe as well, if that might help it any.