Well, if nothing was an issue (i.e. money, jobs, family, etc), then more than likely California or even certain places in Arizona possibly. I actually really liked Seattle area when I visited but don't think I could deal with the rain. Overall, I think I like the West Coast better weather-wise and asethically speaking.
Realistically speaking? I'm almost 95% sure I'm going to end up in South Carolina within a year or two tops. I think it wins out on all counts. Close enough to family, without being too far, nice weather most of the year (the summer humidity and bugs will be killer for me, but I guess I can't win on ALL counts), the job market isn't great but I hear for young college aged individuals, there is starting to be more opportunity. Lots of beaches, not too fast paced or big (I hate heavy traffic and lots of congestion) etc.