I feel that there's not really a big difference, but then again it all depends. There's just so many options out there so if you find something that your dog likes and has good nutritional value then just go with it. You could also go with both assuming the budget allows. If you're especially worried about vitamins/proteins/health benefits, you can look into supplements and wellness protocols. Buddy Custard is one that I've heard works well, but like I said there are so many options even outside of just the basic dog food so it's a good idea to try a variety of things and see what works for you and your dog.