I've been researching vaccines a bit in papillons in particular. Mia's breeder does limited vacs and as you probably know Hiro died from an adverse reaction to lepto. I found this and it was kind of interesting to me:
Why would that be? What causes certain breeds to have more reactions to shots than others?
ETA: It's from here: Sulean Papillons & Wearable Art
Papillons have been especially prone to reactions to vaccines, flea products,
wormers, boron, Dursban, etc. and should be treated as a sight hound.
They are believed to metabolize products differently than other breeds of
dogs, Rabies vaccines have been of particular concern causing shock and
facial swelling. USE NO LEPTO OR LYME VACCINE Hundreds of deaths have resulted every year due to improper or uninformed treatment of
Papillons. Shock with Renal and Liver Damage, respiratory distress,
swelling of the facial area and ears resulting in loss of circulation all are
observed frequently and may cause permanent damage or result in death.
wormers, boron, Dursban, etc. and should be treated as a sight hound.
They are believed to metabolize products differently than other breeds of
dogs, Rabies vaccines have been of particular concern causing shock and
facial swelling. USE NO LEPTO OR LYME VACCINE Hundreds of deaths have resulted every year due to improper or uninformed treatment of
Papillons. Shock with Renal and Liver Damage, respiratory distress,
swelling of the facial area and ears resulting in loss of circulation all are
observed frequently and may cause permanent damage or result in death.
ETA: It's from here: Sulean Papillons & Wearable Art