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Old 06-19-2013, 07:31 PM
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Default Ivomec Dosage??

Smallest dog is 20 lbs, largest is 80 lbs. I am having a hard time finding out how to dose out Ivermectin. It's costing us $180/MONTH to use Trifexis. So...I googled and found this, does this seem accurate?

1) Take 1 ml (10 mg) of Ivomec***65533; 1% and dilute it to 10 ml total volume which gives a concentration of 10 mg in 10ml solution. Propylene glycol is readily available so it may be used: 1 ml Ivomec***65533; 1% Inj. + 9 ml propylene glycol = 10 ml diluted solution with a concentration of 10 milligrams / 10ml which is the same as 10,000 micrograms / 10ml or 1,000 micrograms per 1 milliliter since 1 milligram = 1,000 micrograms. Label this: ***65533;ivermectin 1,000 mcg / 1ml dilution***65533; and write the date on the label of when it was prepared.

2) The dose range of ivermectin for dogs is 0.003-0.006 milligrams/kg body weight (1kg=2.2 lb) or 3-6 micrograms/kg of body weight. All calculations below use the higher dose of 6 micrograms / kg of body weight or 2.72 micrograms / pound of body weight.

3) Therefore a 100# dog (45.45kg) needs a 272 mcg dose: 45.45 kg x 6 mcg/kg = 272 mcg dose

4) The diluted solution prepared in step #1 contains 10,000 mcg / 10 ml or 1,000 mcg / 1 ml or 100 mcg / 0.1 ml therefore the dose in step #3 can easily be calculated: 272 mcg will be contained in 0.272 ml of the dilution prepared in step #1 which can accurately be measured using a 1 ml insulin or TB syringe which is graduated in tenths of a milliliter (0.1, 0.2, 0.3 ml), and which has 10 markings between each increment of 0.1, 0.2, etc. The 0.272 ml dose is measured by drawing up an amount past the 0.2 ml mark plus 7 of the smaller markings almost to the 0.3 ml mark.

5) Using the following formula, a proper dose can be calculated for any dog whose body weight is known:

_______ Weight of dog in pounds X dose of 2.72 micrograms per pound of body weight/1000 mcg per ml ivermectin dilution prepared in step #1 = dose in milliliters of dilution from step #1

Examples: A dog weighs 77 pounds so 77 x 2.72/1000 = 0.21 ml of dilution given in food once a month

A dog weighs 125 pounds so 125 x 2.72/1000 = 0.34 ml of the dilution given in food once a month

A dog weighs 12 pounds so 12 x 2.72/1000 = 0.03 ml of the dilution given in food once a month

I would use the diluted solution simply because of the 10 fold less chance of error. Measuring 0.21 ml is easily possible while measuring 0.021 ml is prone to error. I would prepare the dilution fresh each season and discard any unused diluted solution at the end of the season. I have read that ivermectin is photolabile meaning it is destroyed by light so both it and the dilution should be stored in a cool, dark place at or below room temperature. It does not seem necessary to refrigerate the solution or the diluted solution.

Yay or nay??
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Old 06-19-2013, 07:36 PM
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Um... I just do 1/10cc per 10lbs using the 1% solution.

I haven't had any problems. And if you have any worries of mdr1, the test is $75.

ETA: a lot of MDR1 m/m use ivermectin for heartworm without issue. The problem seems to come from the higher doses used for mange. I personally probably would use something else if I knew my dog was m/m, but even the university that does the test says the small amount required for hw is ok.

I use a 3ml syringe & needle to draw it out of the vial. I also store mine in the dark box it came in, in the fridge. When I buy it it's not refrigerated, and the package doesn't say anything on it about refrigeration.
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Old 06-19-2013, 07:47 PM
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Storing in a dark place isn't enough, it should be in a dark bottle.
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Old 06-19-2013, 07:51 PM
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Well, I was thinking to dilute it because we have a Border Collie and a Kelpie. They have both been on Heartguard in the past without a problem so I was thinking of diluting it to that concentration. I may just run the tests on both of them AND dilute it...thoughts?

Quote:
Originally Posted by JessLough View Post
Storing in a dark place isn't enough, it should be in a dark bottle.
I did read it was light sensitive, so I will probably do dark bottle in fridge.
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Old 06-19-2013, 07:56 PM
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It doesn't need to be in a dark bottle if you just keep the bottle in the box it comes in and keep it in a cabinet. It doesn't need to be refrigerated, either.
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Old 06-19-2013, 08:13 PM
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Quote:
Originally Posted by sassafras View Post
It doesn't need to be in a dark bottle if you just keep the bottle in the box it comes in and keep it in a cabinet. It doesn't need to be refrigerated, either.
I'm going to dilute so not original bottle
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Old 06-19-2013, 08:18 PM
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I thought you were going to prepare the dilution fresh each time?
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Old 06-19-2013, 08:24 PM
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Quote:
Originally Posted by xpaeanx View Post
I thought you were going to prepare the dilution fresh each time?
Fresh for the season, I read it as.
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Old 06-19-2013, 08:24 PM
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Yea if you're going to dilute it I would just make the doses fresh each time.
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Old 06-19-2013, 08:28 PM
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Quote:
I may just run the tests on both of them AND dilute it...thoughts?
That's what I would do if I were going to use it on my dogs. It has been found in GSDs, too. http://www.vetmed.wsu.edu/depts-vcpl/breeds.aspx
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